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In contrast with mouse thymocytes, mouse ES cells comprise increased levels of complete genomic H3K4me3 and have higher H3K4me3 occupancy on the promoter of the pluripotent gene Oct4 forty six In agreement with this, world decreases in H3K4me3 levels occur during retinoic acid (RA)-induced differentiation of mouse ES cells 47 In addition, there are dynamic adjustments in H3K4me3 profiles at particular units of genes throughout ES cell differentiation.
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